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This chapter is excerpted from 'Department of Startup: Why Every Fortune 500 Should Have One'. The ascent of start-ups on the Fortune 500 ranking, displacing some of the more notable companies raised not only attention but also questions. Fundamentally, start-ups are built on a very different organizational culture as compared to a traditional Fortune 500. Could these cultural differences be the reason why start-ups are in the forefront of technology innovation, disrupting industries dominated by more established competitors and thriving in today's volatile business environment? This book aims to help CEOs, Presidents, Human Resources Practitioners on how they can transform their large corporation to thrive in a fast, social media conscious and unforgiving market a la start-up.