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This chapter is excerpted from 'The DNA of Physician-Leadership: Creating Dynamic Executives'. Increasingly, physicians are transitioning away from being clinicians to becoming health care leaders and administrators. While the reasons for this transition are varied (eg, attractive opportunities, lifestyle choices, personal growth, burnout), the journey to leadership positions is fraught with new and unexpected challenges. It comes without a roadmap. Virtually no training is provided in medical school for the consideration that these physicians may move into leadership positions. In fact, many of the skills they have developed in medical school have narrowed their focus and created very specialized experts. Such specialized skills can actually interfere with preparation for broader leadership positions. Physicians with MBAs are becoming increasingly common, and yet they still find themselves underprepared for the challenges of physician-leadership. The DNA of Physician-Leadership serves to fill that important gap. The DNA of Physician-Leadership is a practical, step-by-step guide for health care professionals, providing them the necessary tools required to be successful in leadership positions, including: Understanding typical physician psychology; Comprehending health care as a business; Learning the essence of leadership; Creating high-performing teams; Delegating for impact; Setting a compelling vision; Communicating with influence; and Negotiating successfully. This book comes from real-life examples and experiences. It is complete with case studies, exercises, and a unique Coach's Corner, summarizing each chapter and providing specific suggestions for leadership development. In addition, we provide significant insights into the typical personalities of physicians and what they will need to change or modify to become successful leaders. We believe that no such practical guide currently exists in the literature. The audience for our book includes physicians who are already in leadership positions or considering transitioning into them.