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This is the first of a two-case series (302-031-1 and 302-032-1). The two-part case study enables students to grapple with the multi-dimensional nature of organisational transformation processes. It illustrates varied leadership roles, multiple cultural challenges, and the complex strategic choices involved in transforming a large, successful company in a rapidly changing industry (chemicals-pharmaceuticals). Students will analyse how the company learned from several cross-border mergers and acquisitions, and from numerous attempts to introduce new structures. These insights can apply to many companies with years of international experience that now need to work toward becoming global. The cases are best used in a strategic change or business transformation course of an MBA or similar graduate programme. It can be used at the outset to alert the students to the various dimensions that will be treated in subsequent sessions. Alternatively, it can serve as a capstone to such a course, so that students draw together the multiple concepts dealt with in previous sessions. A video ''Shock Therapy: The Formation of Aventis'' (302-031-3) is available to accompany the case series.