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The case describes the manner in which SciQuest.com''s business-to- business (B2B) e-marketplace was developed and the system architecture of this e-marketplace. It also explains how the company implemented an operations fulfilment solution in the marketplace and the benefits derived from it. The case is designed to help students critically analyse the systems architecture of a B2B e-marketplace. Students should essentially gain a general understanding of the following: (1) the need for the development of a B2B marketplace; (2) the development procedure, the architecture of a B2B e-marketplace, and the problems faced by SciQuest.com; (3) the systems architecture of an order management solution; (4) the value proposition offered by B2B e-marketplaces; and (4) the revenue model of a B2B e-marketplace in general, and of SciQuest in particular. The case is intended for MBA/PGDBM level students as a part of the knowledge, information and communication systems management curriculum.