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This is the first of a two-case series. This case presents the situation faced by Ofra Sherman, the General Manager of Wellcome Israel, a subsidiary of Wellcome PLC and represented in Israel by Promedico, during the merger of the pharmaceutical companies Glaxo and Wellcome. Sherman faced the difficulties of managing her team during the transition and the anticipated loss of the organisation's independence. These problems were exacerbated by the division's uncertain relationship to its parent company. The case provides opportunities for understanding ambiguous change situations and their implications for career; looking at mergers and takeovers from the point of view of middle managers; and considering externally-imposed changes to successful teams.