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The nation-state has begun to crumble. What is emerging in its place is the region-state, which is defined by economic activity, not political borders. The factors behind the shift are threefold: First, people, capital, and information can move across borders so quickly that economic decisions are often based on the fear that needed resources will go elsewhere. Second, as consumers see how other people live, they pressure their governments to give them access to the best and cheapest products. And third, as governments defer to special interests and try to provide constituents with a civil minimum of services, they invest inefficiently and as a result destroy wealth. Although political leaders will resist acknowledging the demise of the nation-state, only those who can accept it and promote region-states within and across their borders will be able to provide the best quality of life for their constituents.