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This is part of a case series. This case describes the factors that allow one inner city hospital - Children's Hospital, Newark - to develop a program to treat children with AIDS that becomes a national and international model. It sketches the ways in which highly specialized pediatric care comes to be delivered in a package that includes social work and other support services for some of Newark's poorest families - hit hard by the AIDS epidemic. The case allows exploration of how an innovative program developed, as well as raising specific AIDS treatment and funding issues which threaten the long-term prospects of the Children's Hospital program. Successful programs dealing with major social problems often invite replication. Yet the attempt to use a successful program as a model raises the question of whether the factors which led to success can - or must - themselves be replicated. This case explores the process by which the state of New Jersey decided to use the Children's Hospital, Newark program for children with AIDS as a statewide model. It examines both the process of deciding where else the program should be established and two sites which ultimately are chosen - one seemingly successful, the other troubled.